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The Research Collection

Key research on issues relating to hypoparathyroidism, hyperparathyroidism and surgery.

Some of these articles will require password entry.

2017

The 5th National Audit Report 2017 from the BAETS Audit, now re-named as the United Kingdom Registry of Endocrine and Thyroid Surgery (UKRETS). David Chadwick, Robin Kinsman & Peter Walton on behalf of BAETS


2016

Management of Hypoparathyroidism: Summary Statement and Guidelines Report #1 from the First International Conference on “The Diagnosis, Management and Treatment of Hypoparathyroidism” held in Florence, Italy May 7–9, 2015Maria Luisa Brandi1 , John P. Bilezikian2 , Dolores Shoback3 , Roger Bouillon4 , Bart Clarke5 , Rajesh V. Thakker6 , Aliya Khan7 , and John T. Potts Jr J Clin Endocrinol Metab p


Effect of Low Vitamin D on Volumetric Bone Mineral Density, Bone Microarchitecture, and Stiffness in Primary Hyperparathyroidism. J Clin Endocrinol Metab. 2016 Mar;101(3):905-13. doi: 10.1210/jc.2015-4218. Epub 2016 Jan 8.Walker MD(1), Nishiyama KK(1), Zhou B(1), Cong E(1), Wang J(1), Lee JA(1), Kepley A(1), Zhang C(1), Guo XE(1), Silverberg SJ(1).


Effects of Parathyroid Hormone Administration on Bone Strength in Hypoparathyroidism.
Rubin MR1, Zwahlen A2, Dempster DW3,4, Zhou H4, Cusano NE1, Zhang C1, Müller R2, Bilezikian JP1.J Bone Miner Res. 2016 Jan 1. doi: 10.1002/jbmr.2777. [Epub ahead of print]

 

 

G-Protein Subunit-α11 Loss-of-Function Mutation, Thr54Met, Causing Familial Hypocalciuric Hypercalcemia Type 2 (FHH2).
Gorvin CM, Cranston T, Hannan FM, Rust N, Qureshi A, Nesbit MA, Thakker RV. J Bone Miner Res. 2016 Jan 5. doi: 10.1002/jbmr.2778. [Epub ahead of print]

 

 

2015

European Society of Endocrinology Clinical Guideline: Treatment of chronic hypoparathyroidism in adults 
Jens Bollerslev1,2,*, Lars Rejnmark3,*, Claudio Marcocci4 , Dolores M Shoback5 , Antonio Sitges-Serra6 , Wim van Biesen7 and Olaf M Dekkers8,9,10

 

PTH(184replacement therapy for the treatment of hypoparathyroidism.
Cusano NE1, Rubin MR1, Bilezikian JP1. Expert Rev Endocrinol Metab 2015 Jan 1;10(1):5-13.

  

Hypoparathyroidism
Koschker AC1Burger-Stritt S1Hahner S1. Dtsch Med Wochenschr 2015 Aug;140(16):1195-7. doi: 10.1055/s-0041-102880. Epub 2015 Aug 11.

  

The Syndrome of Familial Hypoparathyroidism, Sensorineural Deafness and Renal Dysplasia.
Meena RLMaloo SKSamar NRuhela ASaini SJ Assoc Physicians India. 2015 Jun;63(6):73-5.

 

Defining the syndromes of parathyroid failure after total thyroidectomy
Leyre Lorente-Poch,1,2 Juan J. Sancho,1,2 Jose Luis Muñoz-Nova,3 Patricia Sánchez-Velázquez,1,2 and Antonio Sitges-Serracorresponding author1,2 Gland Surg. 2015 Feb; 4(1): 82–90.

 

 

Pseudohypoparathyroidism type 1a due to a novel mutation in the GNAS gene.
Lemos MC, Christie PT, Rodrigues D, Thakker RV.Clin Endocrinol (Oxf). 2015 Sep 24. doi: 10.1111/cen.12953. [Epub ahead of print] No abstract available


Parathyroid autotransplantation during total thyroidectomy. Results of a retrospective study.
Tartaglia F1, Blasi S2, Giuliani A3, Merola R4, Livadoti G5, Krizzuk D6, Tortorelli G7, Tromba L8.Int J Surg. 2015 Dec 18. pii: S1743-9191(15)01447-8. doi: 10.1016/j.ijsu.2015.05.059. [Epub ahead of print]

 

An open-label extension study of parathyroid hormone rhPTH (1-84) in adults with hypoparathyroidism
Lakatos P1, Bajnok L2, Lagast H3, Valkusz Z4.Endocr Pract. 2015 Dec 18. [Epub ahead of print]

 

Management of Graves Disease: A Review.
Burch HB, Cooper DS. JAMA. 2015 Dec 15;314(23):2544-54. doi: 10.1001/jama.2015.16535. Review.

 

 

2014

Systematic review and meta-analysis of predictors of post-thyroidectomy hypocalcaemia.Edafe O1, Antakia R, Laskar N, Uttley L, Balasubramanian SP.Br J Surg. 2014 Mar;101(4):307-20. doi: 10.1002/bjs.9384. Epub 2014 Jan 9.

 

Treatment related morbidity in differentiated thyroid cancer-a survey of clinicians. Edafe O1, Wadsley J, Harrison BJ, Balasubramanian SP.Thyroid Res. 2014 Mar 11;7(1):3. doi: 10.1186/1756-6614-7-3.

  

Incidence and predictors of post-thyroidectomy hypocalcaemia in a tertiary endocrine surgical unit.Edafe O1, Prasad P, Harrison BJ, Balasubramanian SP.Ann R Coll Surg Engl. 2014 Apr;96(3):219-23. doi: 10.1308/003588414X13814021679753.

 

Understanding the burden of illness associated with hypoparathyroidism reported among patients in the PARADOX study. Hadker, Eden, Sanders, Lagast, Clarke Endocrine Practice Vol20 No7 July 2014 

 

Impact of postoperative magnesium levels on early hypocalcaemia and permanent hypoparathyroidism after thyroidectomy.Garrahy A1, Murphy MS, Sheahan P.Head Neck. 2014 Dec 9. doi: 10.1002/hed.23937. 


Prevalence of hypocalcaemia and its associated features in 22q11·2 deletion syndrome Cheung EN1, George SR, Costain GA, Andrade DM, Chow EW, Silversides CK, Bassett AS.Clin Endocrinol (Oxf). 2014 Aug;81(2):190-6. doi: 10.1111/cen.12466. Epub 2014 May 27.

 

Prolonged spontaneous normocalcaemia in pseudohypoparathyroidism from resorption of soft tissue calcium deposits: a cautionary tale. Carter EE, Kline G, BMJ Case Rep 2014 Jan 30;2014. pii: bcr2013202729. doi: 10.1136/bcr-2013-202729.

   

 


Marcocci CBollerslev JKhan AAShoback DM.  J Clin Endocrinol Metab. 2014 Oct;99(10):3607-18. doi: 10.1210/jc.2014-1417. Epub 2014 Aug 27.

 

 

Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Fourth International Workshop.
Bilezikian JP1, Brandi MLEastell RSilverberg SJUdelsman RMarcocci CPotts JT Jr.J Clin Endocrinol Metab. 2014 Oct;99(10):3561-9. doi: 10.1210/jc.2014-1413. Epub 2014 Aug 27.



2013 

Efficacy and safety of recombinant human parathyroid hormone (1-84) in hypoparathyroidism (REPLACE): a double-blind, placebo-controlled, randomised, phase 3 study. Mannstadt M1Clarke BL2Vokes T3Brandi ML4Ranganath L5Fraser WD6Lakatos P7Bajnok L8Garceau R9Mosekilde L10Lagast H9Shoback D11,Bilezikian JP12Lancet Diabetes Endocrinol. 2013 Dec;1(4):275-83. doi: 10.1016/S2213-8587(13)70106-2. Epub 2013 Oct 7.

 

2012

Hypoparathyroidism
A.Khan Best Practice & Research: Clinical Endocrinology & Metabolism 26(4):517-22 · August 2012 

 

A protocol for avoidance of post-thryoidectomy hypocalcaemia, results of first 12 months’ audit
Leo Alexandre, Simon Pain & Jeremy Turner Endocrine Abstracts (2012) 28 P45 

 

Predictors of Hypocalcemia after Thyroidectomy: Results from the Nationwide Inpatient Sample RL. BaldassarreDC. ChangKT. BrumundM.Bouvet. IRSN Surg. 2012;2012:838614

 

Influence of experience on performance of individual surgeons in thyroid surgery: prospective cross sectional multicentre study
Duclos et al, BMJ 2012:344

 

Mini-review: new therapeutic options in hypoparathyroidism.
Cusamo,NERubin MRSliney J JrBilezikian JP. Endocrine 2012 Jun;41(3):410-4. Epub 2012 Feb 7.

 

Normocalcemic primary hyperparathyroidism: A newly emerging disease needing therapeutic intervention
Gonzalo Díaz-Soto, María Teresa Julián, Manel Puig-Domingo HORMONES 2012, 11(4):390-396

 

 

 

2011

Hypoparathyroidism in the adult: Epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research
JP Bilezikian, A Khan, JT Potts, ML Brandi, BL Clarke, D.Shoback, H.Juppner, P. D'Amour, J.Fox, L. Rejnmark, L.Mosekilde, MR. Rubin, D.Dempster, R.Gafni, MT Collins, J.Sliney, J.Sanders.Journal of Bone and Mineral Research,Volume 26Issue 10pages 2317–2337October 2011. 


Synthetic human parathyroid hormone 1-34 replacement therapy : A randomised crossover trial comparing pump versus injection in the treatment of chronic hypoparathyroidism.
K.Winer et al J,Clim Edocri ol. Metab 2011 Nov 16. [Epub ahead of print]

 

The effect of adding PTH(1-84) to conventional treatment of hypoparathyroidism: a randomized, placebo-controlled study. Sikjaer, Reinmark, Rolighed, Heinkendorff, Mosekiilde, Hypoparathyroidism Study Group;  J Bone Miner Res2011 Oct;26(10):2358-70. doi: 10.1002/jbmr.470.

 

2010

Hypocalcaemia after thyroidectomy: the need for improved defenitions
Jessie Wu & Barney Harrison WJES Jan-April 2010;2(1):17-20


Diagnosis and management of vitamin D deficiency
Pearce and Cheetham BMJ Jan 2010;340;b5664


Outcome of protracted hypoparathyroidism after total thyroidectomy.Sitges-Serra ARuiz SGirvent MManjón HDueñas JPSancho JJ. 2010 Nov;97(11):1687-95.

 

Long-term treatment of 12 children with chronic hypoparathyroidism: a randomized trial comparing synthetic human parathyroid hormone 1–34 versus calcitriol and calcium. Winer KKSinaii NReynolds JPeterson DDowdy KCutler GB Jr. J Clin Endocrinol Metab. 2010;95:26808.


Parathyroid Disorders and Diseases Altering Calcium Metabolism. 
Thakker R (2010) In: Warrell, D.A., Cox, T.M. and Firth, J.D. (Eds.) Oxford textbook of medicine. Volume 2, 5th edn. Oxford, UK: Oxford University Press. Chapter 13.6
.


Therapy of hypoparathyroidism with intact parathyroid hormone.
Rubin MRSliney J JrMcMahon DJSilverberg SJBilezikian JP. Osteoporosis Int. 2010 Nov;21(11):1927-34. Epub 2010 Jan 22.

 

2009

A Practical Approach to Hypocalcaemia in Children
Nick Shaw in Allgrove J, Shaw NJ (eds): Calcium and Bone Disorders in Children and Adolescents.Endocr Dev. Basel, Karger, 2009, vol 16, pp 73–92

 

Guidelines for the management of asymptomatic primary hyperparathyroidism: summary statement from the Third International Workshop. 
Bilezikian JPKhan APotts JT Jr.J Clin Endocrinol Metab. 2009;94:3359.

 

Medical management of asymptomatic primary hyperparathyroidism: proceedings of the Third International Workshop. Khan A, Grey A, Shoback D. J Clin Endocrinol Metab. 2009;94:373–81. doi: 10.1210/jc.2008-1762. [PubMed] [Cross Ref]

 

Anti-Parathyroid and Anti-Calcium Sensing Receptor Antibodies in Autoimmune Hypoparathyroidism
Brown, E. Endocrinology and Metabolism Clinics. 2009;38(2).

 

2008

Diagnosis & Management of Hypocalcaemia: Clinical Review
Cooper and Gittoes  BMJ  2008;336:1298-1302 (7 June)2008

 

Unrecognised Severe Hypovitaminosis D
Sievenpiper, McIntrye, Verrill, Quinton, Pearce BMJ  2008;336:1371-1374 (14 June)

 

Hypoparathyroidism: Is It Time for Replacement Therapy?
Horwitz and Stewart (93 (9): 3307 JECM 2008) Click PDF download

 

Hypoparathyroidism : Clinical Review
Shoback, D NEJM Vol 359:391-403 July 2008

 

Vitamin D status in postmenopausal women living at higher latitudes in the UK 
Macdonald, Macvroeid, Barr,Black , Fraser, Reid  (Vol 42:5, 996-1003, May 2008 Bone)

 

DiGeorge Syndrome presenting as late onset hypocalcaemia in adulthood
Johnston, Donnelly, Morrison and Hunter Ulster Med J 2008; 77 (3) 201-202

 

Effects of once versus twice -daily PTH 1-34 therapy in children with HPTH
Winer, Sinaii, Peterson, Sainz, Cutler  JCEM 2008 Sep;93(9):3389-952008

 

Dynamic and structural properties of the skeleton in hypoparathyroidism.
J Bone Miner Res. 2008;23(12):2018-34.Rubin MR, Dempster DW, Zhou H, Shane E, Nickolas T, Sliney J,Silverberg SJ, Bilezikian JP.  

 

Hypoparathyroidism after total thyroidectomy: A prospective study
Asari RKoperek OKaczirek K, et al. 
Arch Surg.2008;143:1327.


Best practice in primary care pathology: review 11.
Smellie, W.S., Vanderpump, M.P., Fraser, W.D. et al. (2008
Journal of Clinical Pathology 61(4), 410-418.

 

2007

Vitamin D Deficiency: Clinical Review
Holick, MF  NEJM Volume 357:266-281 July 2007

 

Cyclical changes in calcium metabolism across the menstrual cycle in women with premenstrual dysphoric disorder
Thys-Jacobs, McMahon, Bilezikian JCEM 2007

 

Hypocalcemic tetany in the newborn as a manifestation of unrecognized maternal primary hyperparathyroidism. 
Pieringer H, Hatzl-Griesenhofer M, Shebl O, et al.  Wien Klin Wochenschr. 2007;119:129-131


The impact of single parathyroid gland autotransplantation during thyroid surgery on postoperative hypoparathyroidism: a multicenter study. Transplant Proc.Testini M, Rosato L, Avenia N, et al.  2007;39:225-230.

 

2006

Withdrawal of alfacalcidol supplements following thyroidectomy: baseline plasma PTH predicts successful outcome
Morris, M & Perros, P  Presented at European Congress of Endocrinology, Glasgow 2006 (Endocrine Abstracts 11: P919 2006)

 

2005

A comparison of corrected serum calcium levels to ionized calcium levels among critically ill surgical patients.
Byrnes MC, Huynh K, Helmer SD, et al.  Am J Surg. 2005;189:310-314.


Magnesium deficiency in critical illness
Tong GMRude RKJ Intensive Care Med. 2005;20:317.

 

2004

Severe hypocalcaemia after being given intravenous bisphosphonate
Peter R, Mishra V, Fraser WD BMJ, Feb 2004 328(7435):335-336

 

Minimally invasive parathyroid surgery
Udelsman R, Donovan PI.  World J Surg. 2004;28:1224-1226

 

2003

 

The impact of clinical guidelines on surgical management in patients with thyroid cancer 
Phillips AW, Fenwick JD, Mallick UK, Perros P Clinical Oncol Sept 2003 Vol15:8: 485-489


The impact of surgical technique on postoperative hypoparathyroidism in bilateral thyroid surgery: a multivariate analysis of 5846 consecutive patients
Thomusch OMachens ASekulla C, et al.  Surgery. 2003;133:18095.

 

Long-term treatment of hypoparathyroidism: A randomized controlled study comparing parathyroid hormone versus calcitriol and calcium.
Winer KK, Ko CW, Reynolds JC, et al. J Clin Endocrinol Metab. 2003;88:4214-4220.

 

Prevention, evaluation, and management of complications following thyroidectomy for thyroid carcinoma. Zarnegar RBrunaud LClark OHEndocrinol Metab Clin North Am. 2003;32:483502.

 

2002

Well-being, mood and calcium homeostasis in patients with hypoparathyroidism receiving standard treatment with calcium and vitamin D
Arlt, Fremerey, Callies, Reincke, Schneider, Timmermann,  B Allolio. European Journal of Endocrinology 146: 215 - 222, Feb 2002 

 

2001

Hypocalcaemic Disorders
Thakker, RV, Medecine Vol 29 pp57-59, 2001.

 

Effect of parathyroid hormone (1–34) on fractures and bone mineral density in postmenopausal women with osteoporosis. Neer RMArnaud CDZanchetta JR, et al. N Engl J Med. 2001;344:143441.

 

2000

Genetic ablation of parathyroid glands reveals another source of parathyroid hormoneGunther TChen ZFKim J, et al.Nature.2000;406:199203.

 

1999

Oestrogen and calcium homeostasis in women with hypoparathyroidism
Oestrogen status can affect the requirement for vitamin D in women with hypoparathyroidism
Janet McIlroy, Frances Dryburgh,John Hinnie, Dargie, Al-Rawi, Department of Clinical Biochemistry, Glasgow Royal Infirmary, BMJ 1999;319:1252-1253

 

1998

Hypoparathyroidism
Bilezikian JPThakker RV
Current Opinion in Endocrinology. 1998;4:42732.


1997

Postoperative tetany in patients with Graves' disease: a risk factor analysis.


   
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